| GIORNATA | DATA | CASA | TRASFERTA | RISULTATO |
| 1 | 12-09-2021 | MANFREDONIA | VIGOR TRANI | 3-0 |
| 2 | 19-09-2021 | SAN SEVERO | MANFREDONIA | 2-1 |
| 3 | 26-09-2021 | MANFREDONIA | BORGOR.MOLFETTA | 0-2 |
| 4 | 03-10-2021 | CANOSA | MANFREDONIA | 0-1 |
| 5 | 10-10-2021 | MANFREDONIA | REAL SITI | 1-1 |
| 6 | 17-10-2021 | ATLETICO VIESTE | MANFREDONIA | 2-2 |
| 7 | 24-10-2021 | MANFREDONIA | UC BISCEGLIE | 3-2 |
| 8 | 31-10-2021 | TRINITAPOLI | MANFREDONIA | 1-2 |
| 9 | 07-11-2021 | MANFREDONIA | CORATO | 1-2 |
| 10 | 14-11-2021 | MANFREDONIA | TEAM ORTA NOVA | 2-0 |
| 11 | 21-11-2021 | CITTA’ DI MOLA | MANFREDONIA | 3-0 |
| 12 | 28-11-2021 | MANFREDONIA | SAN MARCO | 6-0 |
| 13 | 05-12-2021 | BARLETTA | MANFREDONIA | 0-0 |
| 14 | 12-12-2021 | VIGOR TRANI | MANFREDONIA | 1-4 |
| 15 | 19-12-2021 | MANFREDONIA | SAN SEVERO | 2-0 |
| 16 | 30-01-2022 | BORGOR.MOLFETTA | MANFREDONIA | 2-1 |
| 17 | 06-02-2022 | MANFREDONIA | CANOSA | 0-1 |
| 18 | 13-02-2022 | REAL SITI | MANFREDONIA | 2-2 |
| 19 | 20-02-2022 | MANFREDONIA | ATLETICO VIESTE | 2-0 |
| 20 | 27-02-2022 | UC BISCEGLIE | MANFREDONIA | 1-1 |
| 21 | 06-03-2022 | MANFREDONIA | TRINITAPOLI | 0-1 |
| 22 | 13-03-2022 | CORATO | MANFREDONIA | 2-0 |
| 23 | 20-03-2022 | TEAM ORTA NOVA | MANFREDONIA | 0-2 |
| 24 | 27-03-2022 | MANFREDONIA | CITTA’ DI MOLA | 2-1 |
| 25 | 03-04-2022 | SAN MARCO | MANFREDONIA | 1-3 |
| 26 | 10-04-2022 | MANFREDONIA | BARLETTA | 2-1 |